Architect Dame Zaha Hadid, known for designs such as the London Aquatics Centre for the 2012 Olympic Games and the Riverside Museum in Glasgow, has died from a heart attack aged 65.
She contracted bronchitis while in Miami earlier this week and died in hospital this morning, her company said.
In a statement it said: "It is with great sadness that Zaha Hadid Architects have confirmed that Dame Zaha Hadid, DBE died suddenly in Miami in the early hours of this morning.
"She had contracted bronchitis earlier this week and suffered a sudden heart attack while being treated in hospital."
In 2012 Dame Zaha was honoured in the Queen's Birthday Honours list for services to architecture.
Mayor of London, Boris Johnson, was one of the first people to pay tribute to the architect, tweeting: "So sad to hear of death of Zaha Hadid, she was an inspiration and her legacy lives on in wonderful buildings in Stratford & around the world."
Earlier this year the Royal Institute of British Architects announced that Dame Zaha would receive the 2016 Royal Gold Medal.
She was the first woman to be awarded the honour - personally approved by the Queen - in her own right.
Speaking in February on BBC Radio 4's Desert Island Discs, the 65-year-old said: "I don't really feel I'm part of the establishment.
"I'm not outside, I'm on the kind of edge, I'm dangling there. I quite like it."
She added: "I'm not against the establishment per se. I just do what I do and that's it."
In the UK, Dama Zaha's most recognisable works also include Cardiff Bay Opera House while, globally, her notable designs include Guangzhou Opera House in China and the Vitra Fire Station in Germany.
Dragons' Den star Den Kelly Hoppen also paid tribute to the architect, tweeting: "Deeply saddened by the news of Zaha Hadid's death. She was an iconic architect who pushed the boundaries to another level xx #ZahaHadid"
Culture Minister Ed Vaizey also posted on Twitter, saying that Dame Zaha "made a huge contribution to contemporary architecture".
Ms Hadid won acclaim in Scotland for designing the popular Riverside Museum in Glasgow, known for its distinctive roof structure.
Muriel Gray, chair of the board of governors at the Glasgow School of Art, tweeted a picture of the Riverside Museum with the message: "Horrible shocking news that Zaha Hadid, incredible architectural trailblazer has just died. Huge loss to design."
Glasgow City Council leader Frank McAveetey said he was "sorry to hear of the sudden death" of Ms Hadid.
Jane Duncan, president of the Royal Institute of British Architects, described news of Dame Zaha's death as "absolutely terrible".
She said: "Dame Zaha Hadid was an inspirational woman, and the kind of architect one can only dream of being. Visionary and highly experimental, her legacy despite her young age, is formidable.
"She leaves behind a body of work from buildings to furniture, footwear and cars, that delight and astound people all around the world."
She concluded by saying: "The world of architecture has lost a star today."
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