NO trains will run from Glasgow Central to Euston station for three consecutive weekends, including the August bank holiday.
There will be no trains to or from the London station on August 18-19, August 25-27 and September 1-2.
Network Rail is urging West Coast main line passengers to avoid all but essential rail travel to and from the capital over the three weekends.
The station is closing as part of Britain's Railway Upgrade Plan, which includes Network Rail replacing North Wembley junction - a major intersection on Europe's busiest mixed-use railway.
An amended, hourly service will run between between Preston and Glasgow Central instead.
Customers travelling between London and Glasgow Central have been advised to use London North Eastern Railway services between London Kings Cross and Edinburgh.
Martin Frobisher, route managing director for Network Rail's London North Western route, said: "There is never an ideal time to shut the railway but these three weekends are the least disruptive times to do it.
"We have worked together for the past three years with train operators to carefully plan this closure of the railway in a way that minimises impact on customers.
"It's vital the track at North Wembley is replaced to continue to safely meet the huge demand of passenger and freight rail services on the West Coast main line. This work will result in better, more reliable journeys in future."
Peter Broadley, executive director for customer, operations and safety at Virgin Trains on the West Coast line, said: "With no services in to or out of Euston we strongly advise our customers to avoid travelling to London on the days affected.
"We know this will impact on people's travel plans, particularly over a bank holiday weekend, so we encourage customers to plan ahead and where possible travel at other times."
While trains are not running out of Euston, alternative options include rail replacement buses and tickets being valid on other reasonable journeys.
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