Nicola Sturgeon said any leader who doesn't take protecting the lives of citizens seriously should think whether they are "fit for office".
The First Minister was asked about Dominic Cummings' claim that Boris Johnson was prepared to let people over 80 die in order to protect the economy.
The First Minister said that she did not know what he did or didn't say but was "sceptical" about anything Dominc Cummings says.
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She was asked about the claims at her latest Covid briefing, where she confirmed another 13 coronavirus deaths and 1,604 new cases in the past 24 hours.
Sturgeon urged those still to get the vaccine to come forward and get the jag to provide more people with protection to allow more restrictions to be lifted next month.
She said: "As long as there remains a proportion without the vaccine, that leaves us with a vulnerability,
"If you know a young person who hasn’t had it, please encourage them to get it."
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Asked whether Boris Johnson should resign over the Dominic Cummings claims, she said: "I don’t know what Boris Johnson said or didn’t say, so it’s probably not appropriate to comment on it in any detail other than to say nobody in a position like mine or Boris Johnson’s should be glib about human life, whether about a young person, adult or older person."
Cummings said in a BBC interview, the Prime Minister was perpared to let Covid "wash through the country" rather than destroy the economy.
He said Johnson did not want to re-impose tougher restrictions last autumn because those dying were "essentially all over 80".
Sturgeon said:"There is a heavy responsibility on us and no decision can save every live.
"Any leader who doesn’t take that seriously should be asking themselves if they are fit for office."
She added: "Last Autumn, Boris Johnson appeared to be reluctant to impose restrictions."
However, she added: "I’ve been a critic of Dominic Cummings. I’m not going to suddenly decide he speaks gospel truth. I would be sceptical of everything he says."
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