Four teenagers are in hospital after a car went off-road and into water.
The group were in a grey Ford Ka which was travelling west on the A721 towards Carluke on Monday evening.
It left the carriageway near Crawfordwalls Bridge at around 10.20pm and came to a rest partially submerged in a burn.
999 crews were called to the scene of the incident and a 17-year-old male was airlifted to the Royal Infirmary of Edinburgh.
He is currently fighting for his life in hospital.
Meanwhile, a 19-year-old man was taken to the Queen Elizabeth University Hospital and two males aged 18 and 19 were taken to Wishaw University Hospital.
The road was closed to allow for collision investigation to take place.
Officers are urging anyone who may have seen what happened to the Ka before it left the road to get in touch.
Anyone who has dashcam footage near the scene may also have vital information.
Sergeant Jack Swindells said: “An investigation is underway as we aim to establish the full circumstances of what happened.
"I am appealing to any motorists who were travelling on the A721 Kilncadzow / Carnwath Road who may have seen the Ford Ka prior to it leaving the road.
"I’d also ask anyone with dash cam equipment to check their footage as there may be images of the vehicle which could assist our inquiries.”
Anyone with information is asked to contact Police Scotland via 101, quoting incident number 4082 of June 10, 2024.
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